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According to randomised controlled trials, you start losing weight immediately after taking Rybelsus. After one month, the average weight loss on Rybelsus is around 2kg; after two months, it’s over 3kg.

What does Rybelsus do to your body?

Rybelsus (oral semaglutide) is a GLP-1 receptor agonist. It mimics a fullness hormone called GLP-1.

Rybelsus reduces appetite and hunger by interacting with the brain’s appetite control centre, the hypothalamus. This effect on the brain helps you eat fewer calories and starts almost immediately after taking the pill.

However, you might notice your hunger levels rising and falling in the first 4-5 weeks you take Rybelsus.

It can take around 4-5 weeks for Rybelsus to reach a level in the body we call a steady state. A steady state is when the drug’s levels in the body remain consistent rather than spiking and falling.

Interestingly, this initial weight loss is no different to other weight loss treatments or the impact of diet interventions on weight loss. The real effect of oral semaglutide is seen beyond three months.

Oral semaglutide is a long-acting medication that’s started at a lower dose to reduce the number and severity of side effects as it’s built up to a higher maintenance dose.

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